COMLEX Level 1 is the first licensure exam for DO students in the United States. It assesses foundational biomedical science, clinical problem solving, and osteopathic principles and practice. Many schools require a passing result to progress and you need it for residency eligibility.
Most DO students sit for Level 1 after completing preclinical coursework, typically near the end of second year, once their school confirms eligibility. Register early so you can choose a comfortable testing window.
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Level 1 questions are organized across two NBOME “dimensions.”
Application of knowledge for osteopathic practice, osteopathic principles and manipulative treatment, patient care and procedural skills, practice based learning and improvement, professionalism, interpersonal and communication skills, and systems based practice.
Presentations drawn from major systems and patient contexts, including musculoskeletal, respiratory, cardiovascular and hematology, gastrointestinal and nutrition, genitourinary and renal, nervous system and mental health, endocrine and metabolism, integumentary, human development and reproduction, and community health and wellness.
Pick a date that follows core systems and leaves time for review and full length practice.
Use active recall, spaced repetition, and mixed question sets. Track weaknesses by system and competency.
Do timed blocks and full simulated days. Rehearse how you will use the pooled 60 minute break.
Try the tutorial and sample items so navigation is automatic on exam day.
Periodically check readiness with practice exams to guide what you review next.
Turn misses into brief takeaways you review twice a week.
Yes. Level 1 reports as pass or fail.
Expect eight sections of single best answer questions, roughly 44 per section.
About nine hours including tutorial and breaks, with two sessions of roughly four hours each and a pooled 60 minutes for breaks.
Most students test after preclinical coursework and before or early in clinical year. Choose a window that aligns with your school calendar and study progress.
Retake rules and waiting periods are set by NBOME and can change. Check the current NBOME policy before you plan additional attempts.
Patient contact and reflective practice make vignettes feel familiar and improve your essays and interviews later. If you want mentored, small cohort clinical exposure that builds cultural competence and teamwork, explore Go Elective programs in Kenya and Tanzania.
Level 1 rewards steady preparation. Know the blueprint, train for a full test day, and keep a simple, repeatable routine. With disciplined practice and a clear plan, you can walk in confident and walk out ready for the next step of your DO journey.
Recent Articles , Pre-health, Medical Electives, MCAT/MSAR/USMLE, Med Schools, Residency,
Author: Go-Elective Abroad
Date Published: Sep 15, 2025
Go Elective offers immersive opportunities for medical students, pre-med undergraduates, residents, nursing practitioners, and PAs to gain guided invaluable experience in busy hospitals abroad. Discover the power of study, travel, and impact.